000			02946nab a22003137a 4500
999			_c6110 _d6110
005			20250625151502.0
008			190109s2018 xxu||||| |||| 00| 0 eng d
040			_aAFVC
100			_aAngelakis, I. _98077
245			_aChildhood maltreatment and adult suicidality : _ba comprehensive systematic review with meta-analysis _cIoannis Angelakis, Emma Louise Gillespie and Maria Panagioti
260			_bCambridge University Press, _c2018
500			_aPsychological Medicine, 2018, Advance online publication, 22 November 2018 (Open access)
520			_aThis comprehensive systematic review and meta-analysis aims to quantify the association between different types of childhood maltreatment and suicidality. We searched five bibliographic databases, including Medline, PsycINFO, Embase, Web of Science and CINAHL, until January 2018. Random-effects meta-analysis was employed followed by univariable and multivariable meta-regressions. Heterogeneity was quantified using the I2 statistic and formal publication bias tests were undertaken. The methodological quality of the studies was critically appraised and accounted in the meta-regression analyses. Data from 68 studies based on n = 261.660 adults were pooled. All different types of childhood maltreatment including sexual abuse [odds ratio (OR) 3.17, 95% confidence interval (CI) 2.76–3.64], physical abuse (OR 2.52, 95% CI 2.09–3.04) and emotional abuse (OR 2.49, 95% CI 1.64–3.77) were associated with two- to three-fold increased risk for suicide attempts. Similar results were found for the association between childhood maltreatment and suicidal ideation. Complex childhood abuse was associated with a particularly high risk for suicide attempts in adults (OR 5.18, 95% CI 2.52–10.63). Variations across the studies in terms of demographic and clinical characteristics of the participants and other core methodological factors did not affect the findings of the main analyses. We conclude that there is solid evidence that childhood maltreatment is associated with increased odds for suicidality in adults. The main outstanding challenge is to better understand the mechanisms which underpin the development of suicidality in people exposed to childhood maltreatment because current evidence is scarce. (Authors' abstract). Record #6110
650			_aCHILD ABUSE _9103
650			_aCHILD SEXUAL ABUSE _9121
650			_aEMOTIONAL ABUSE _9222
650			_aPHYSICAL ABUSE _9439
650		5	_9585 _aSUICIDAL BEHAVIOUR
650		0	_96769 _aSUICIDE IDEATION
650		0	_aSUICIDE _9586
650		0	_aSYSTEMATIC REVIEWS _93140
651		4	_aUNITED KINGDOM _92604
700			_dGillespie, Emma L. _98078
700			_aPanagioti, M. _98079
773			_tPsychological Medicine, 2018, Advance online publication, 22 November 2018 (Open access)
830			_aPsychological Medicine _95903
856			_uhttps://doi.org/10.1017/S0033291718003823
942			_2ddc _cARTICLE