000			03627nab a22004217a 4500
650		4	_9103 _aCHILD ABUSE
999			_c5657 _d5657
005			20250625151441.0
008			171101s2017 -nz||||| |||| 00| 0 eng d
040			_aAFVC
100			_91014 _aDanese, Andrea
245			_aThe origins of cognitive deficits in victimized children : _bimplications for neuroscientists and clinicians _cAndrea Danese, Terrie E. Moffitt, Louise Arseneault, Ben A. Bleiberg, Perry B. Dinardo, Stephanie B. Gandelman, Renate Houts, Antony Ambler, Helen L. Fisher, Richie Poulton, Avshalom Caspi
260			_bPsychiatry Online, _c2017
500			_aAmerican Journal of Psychiatry, 2017, 174(4), 349-361
520			_aObjective: Individuals reporting a history of childhood violence victimization have impaired brain function. However, the clinical significance, reproducibility, and causality of these findings are disputed. The authors used data from two large cohort studies to address these research questions directly. Method: The authors tested the association between prospectively collected measures of childhood violence victimization and cognitive functions in childhood, adolescence, and adulthood among 2,232 members of the U.K. E-Risk Study and 1,037 members of the New Zealand Dunedin Study who were followed up from birth until ages 18 and 38 years, respectively. Multiple measures of victimization and cognition were used, and comparisons were made of cognitive scores for twins discordant for victimization. Results: Individuals exposed to childhood victimization had pervasive impairments in clinically relevant cognitive functions, including general intelligence, executive function, processing speed, memory, perceptual reasoning, and verbal comprehension in adolescence and adulthood. However, the observed cognitive deficits in victimized individuals were largely explained by cognitive deficits that predated childhood victimization and by confounding genetic and environmental risks. Conclusions: Findings from two population-representative birth cohorts totaling more than 3,000 individuals and born 20 years and 20,000 km apart suggest that the association between childhood violence victimization and later cognition is largely noncausal, in contrast to conventional interpretations. These findings support the adoption of a more circumspect approach to causal inference in the neuroscience of stress. Clinically, cognitive deficits should be conceptualized as individual risk factors for victimization as well as potential complicating features during treatment. (Authors' abstract). Record #5657
650		0	_94089 _aADVERSE CHILDHOOD EXPERIENCES
650		0	_aBRAIN DEVELOPMENT _92691
650		5	_9109 _aCHILD DEVELOPMENT
650		5	_aCHILD EXPOSURE TO VIOLENCE _9130
650		0	_94056 _aDunedin Multidisciplinary Health and Development Study
650		5	_9351 _aLONGITUDINAL STUDIES
650		4	_aVICTIMS OF DOMESTIC VIOLENCE _9624
651		4	_aNEW ZEALAND _92588
651		4	_aUNITED KINGDOM _92604
700			_91743 _aMoffitt, Terrie E.
700			_aArseneault, Louise _97144
700			_aBleiberg, Ben A. _97145
700			_aDinardo, Perry B. _97146
700			_aGandelman, Stephanie B. _97147
700			_aHouts, Renate _95652
700			_aAmbler, Antony _97148
700			_aFisher, Helen L. _97149
700			_aPoulton, Richie _91937
700			_9897 _aCaspi, Avshalom
773	0		_tAmerican Journal of Psychiatry, 2017, 174(4), 349-361
830			_94645 _aAmerican Journal of Psychiatry
856			_uhttps://doi.org/10.1176/appi.ajp.2016.16030333 _yRead abstract
942			_2ddc _cARTICLE