| 000 | 02409nab a2200325Ia 4500 | ||
|---|---|---|---|
| 001 | 112759 | ||
| 005 | 20250625151155.0 | ||
| 008 | 110331s2002 eng | ||
| 022 | _a0036-8075 | ||
| 040 |
_aWSS _dAFV |
||
| 100 |
_aCaspi, Avshalom _9897 |
||
| 245 |
_aRole of genotype in the cycle of violence in maltreated children _cCaspi, Avshalom; McClay, Joseph; Moffitt, Terrie E.; Mill, Jonathan; Martin, Judy; Craig, Ian W.; Taylor, Alan; Poulton, Richie |
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| 260 |
_aWashington, DC _bAmerican Association for the Advancement of Science _c2002 |
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| 365 |
_a00 _b0 |
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| 520 | _aThis paper presents the results of a study to determine why some children who are maltreated grow up to develop antisocial behaviour, whereas others do not. The study used data from a large sample of male children in Dunedin (New Zealand) from birth to adulthood. The study found that a functional polymorphism in the gene encoding the neurotransmitter-metabolizing enzyme monoamine oxidase A (MAOA) moderated the effect of maltreatment. As adults 85% of the severely maltreated children with a genotype conferring low levels of MAOA expression developed antisocial outcomes such as conviction for violent crimes. In contrast, maltreated children with a genotype conferring high levels of MAOA expression were less likely to develop antisocial problems. These findings may partly explain why not all victims of maltreatment grow up to victimize others, and provide epidemiological evidence that genotypes can moderate children's sensitivity to a poor environment. The MAOA low-activity genotype did not predict violence in the sample studied; its increased risk for violence was 'activated' by child maltreatment. This suggests the best strategy for violence prevention is preventing child abuse. It is recommended that researchers should measure stressful life events in genetic studies. | ||
| 650 | 2 | 7 |
_2FVC _aNEGLECT _9401 |
| 650 | 2 | 7 |
_9458 _aPREVENTION _2FVC |
| 650 | 2 | 7 |
_9103 _aCHILD ABUSE _2FVC |
| 651 | 2 | 4 |
_aNEW ZEALAND _92588 |
| 700 | 1 |
_aMcClay, Joseph _91663 |
|
| 700 | 1 |
_aMoffitt, Terrie E. _91743 |
|
| 700 | 1 |
_aMill, Jonathan _91716 |
|
| 700 | 1 |
_aMartin, Judy _91644 |
|
| 700 | 1 |
_aCraig, Ian W. _9989 |
|
| 700 | 1 |
_aTaylor, Alan _92191 |
|
| 700 | 1 |
_aPoulton, Richie _91937 |
|
| 500 | _aScience 297(5582) August 2002 : 851-854 | ||
| 773 | 0 | _tScience 297(5582) August 2002 : 851-854 | |
| 942 |
_2ddc _cARTICLE |
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| 999 |
_c2172 _d2172 |
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