000			02816nab a2200385Ia 4500
001			112780
005			20250625151142.0
008			110331s2007 eng
022			_a1091-6490
040			_aWSS _dAFV
100			_aPariante, Carmine M. _91860
245			_aChildhood maltreatment predicts adult inflammation in a life-course study _cPariante, Carmine M.; Danese, Andrea; Caspi, Avshalom; Taylor, Alan; Poulton, Richie _h(electronic resource)
260			_aPrinceton, NJ _bNational Academy of Sciences _c2007
300			_a 7 p. ; computer file : PDF format (498Kb)
365			_a00 _b0
520			_aThis article discusses a study that investigated whether a life-course association between childhood maltreatment and adult inflammation exists. This was tested in the birth cohort of participants of the Dunedin Multidisciplinary Health and Development Study, which has followed a group of 1,000 children born in 1972-73 in Dunedin throughout their lives. Study members were age 32 when they had most recently been assessed in 2004/05. To control for co-occurring risk factors and potential mediating variables, a regression analysis was used to independently estimate the effect of maltreatment on inflammation. The results indicate that 33% of the participants who had experienced maltreatment in childhood showed clinically-relevant inflammation levels at age 32. Of those study members who had not reported maltreatment in childhood, only 18% showed clinically-relevant inflammation levels. The findings suggest that children who are maltreated suffer effects into adult life, long after the maltreatment ends, and that these effects include harm to both physical and psychological health. Several limitations need to be considered in evaluating these findings, for example, replication in other parts of the world would be useful, and it is not known whether these findings generalise to all ethnic groups.
522			_axxu
650	2	7	_2FVC _aDEMOGRAPHICS _9189
650	2	7	_aDunedin Multidisciplinary Health and Development Study _94056
650	2	7	_2FVC _aHEALTH _9283
650	2	7	_2FVC _aHEALTH _9283
650	2	7	_2FVC _aMENTAL HEALTH _9377
650	2	7	_2FVC _aNEGLECT _9401
650	2	7	_2FVC _aSOCIOECONOMIC FACTORS _9568
651		4	_aNEW ZEALAND _92588
650	2	7	_9103 _aCHILD ABUSE _2FVC
700	1		_aDanese, Andrea _91014
700	1		_aCaspi, Avshalom _9897
700	1		_aTaylor, Alan _92191
700	1		_aPoulton, Richie _91937
500			_aProceedings of the National Academy of Sciences of the United States of America 104(4) January 2007 : 1319-1324
773	0		_tProceedings of the National Academy of Sciences of the United States of America 104(4) January 2007 : 1319-1324
856	4		_uhttp://www.pnas.org/cgi/content/abstract/104/4/1319
942			_2ddc _cARTICLE
999			_c1885 _d1885