Gender-affirming hormone therapy and depressive symptoms among transgender adults (Record no. 9173)

MARC details
000 -LEADER
fixed length control field 04197nab a22003977a 4500
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20250625151726.0
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 250324s2025 ||||| |||| 00| 0 eng d
040 ## - CATALOGING SOURCE
Original cataloging agency AFVC
100 ## - MAIN ENTRY--PERSONAL NAME
Personal name Reisner, Sari L.
9 (RLIN) 10381
245 ## - TITLE STATEMENT
Title Gender-affirming hormone therapy and depressive symptoms among transgender adults
Statement of responsibility, etc Sari L. Reisner, David R. Pletta, Alex S. Keuroghlian, Kenneth H. Mayer, Madeline B. Deutsch, Jennifer Potter, Jaclyn M. W. Hughto, Alexander Harris, and Asa E. Radix
260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT)
Name of publisher, distributor, etc JAMA,
Date of publication, distribution, etc 2025
500 ## - GENERAL NOTE
General note JAMA Network Open. 2025, 8(3): e250955
520 ## - SUMMARY, ETC.
Summary, etc Importance: In the US, transgender, nonbinary, and gender diverse (TGD) adults have high rates of depression. Gender-affirming hormone therapy (GAHT) is associated with improved mental health outcomes, yet existing US studies have short follow ups and lack sample diversity.<br/><br/>Objective To evaluate the use of GAHT delivered in primary care as an intervention for moderate-to-severe depressive symptoms in diverse TGD adult patients.<br/><br/>Design, Setting, and Participants: LEGACY was an observational cohort study conducted in federally qualified community health centers in Boston and New York that followed up TGD patients (N = 3592) from calendar years 2016 to 2019 (48 months). Participants included individuals aged 18 years or older, gender identity different from sex at birth, a past 12-month medical visit, and signed patient consent form in the electronic health record (EHR).<br/><br/>Exposures: Prescriptions for GAHT obtained from EHR data, using the date of the first and last GAHT prescription in each calendar year of observation (GAHT within the year vs no GAHT during the year).<br/><br/>Main Outcomes and Measures: A binary outcome of patient-reported moderate-to-severe depressive symptoms was obtained using the validated Patient-Health Questionnaire (PHQ), scoring 10 or greater on the PHQ-9 or scoring 3 or greater on the PHQ-2. Following multiple imputation, generalized estimating equations (GEE) longitudinally modeled GAHT and moderate-to-severe depressive symptoms (n = 20 320 observations) and adjusted for age, gender identity, race and ethnicity, health insurance, federal poverty level, HIV serostatus, number of cohort years, and clinical site.<br/><br/>Results: The median age of the 3592 patients was 28 (IQR, 24-36) years. Race and ethnicity was diverse (1.3% Asian/Pacific Islander, 11.7% Black, 16.1% Hispanic/Latinx, 63.1% White, 6.8% multiracial, and 1.4% other). In addition, 18.9% were nonbinary, 52.1% lived below the federal poverty level, 34.2% were publicly insured, 4.1% were uninsured, and 5.1% were living with HIV. At baseline, 84.5% of the individuals were prescribed GAHT and 15.3% reported moderate-to-severe depressive symptoms. Patients prescribed GAHT had a statistically significantly lower risk of moderate-to-severe depressive symptoms over follow-up compared with those not prescribed GAHT (adjusted risk ratio, 0.85; 95% CI,  0.75-0.98).<br/><br/>Conclusions: and Relevance In this longitudinal observational cohort study, GAHT was associated with lower rates of moderate-to-severe depressive symptoms, highlighting the importance of gender-affirming primary care models for TGD patients. (Authors' abstract). Record #9173
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element DEPRESSION
9 (RLIN) 192
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element HAUORA HINENGARO
9 (RLIN) 5549
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element LGBTQIA+
9 (RLIN) 3453
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element MENTAL HEALTH
9 (RLIN) 377
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element PROTECTIVE FACTORS
9 (RLIN) 4270
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element TAKATĀPUI
9 (RLIN) 4978
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element TRANSGENDER
9 (RLIN) 3315
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element TREATMENT
9 (RLIN) 613
651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME
Geographic name INTERNATIONAL
9 (RLIN) 3624
651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME
Geographic name UNITED STATES
9 (RLIN) 2646
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name Pletta, David R.
9 (RLIN) 13799
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name Keuroghlian, Alex S.
9 (RLIN) 13800
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name Mayer, Kenneth H.
9 (RLIN) 13801
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name Deutsch, Madeline B.
9 (RLIN) 13802
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name Potter, Jennifer
9 (RLIN) 13803
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name Hughto, Jaclyn M. W.
9 (RLIN) 10379
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name Harris, Alexander
9 (RLIN) 13804
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name Radix, Asa E.
9 (RLIN) 13805
773 0# - HOST ITEM ENTRY
Title JAMA Network Open. 2025, 8(3): e250955
830 ## - SERIES ADDED ENTRY--UNIFORM TITLE
Uniform title JAMA Network Open
9 (RLIN) 11657
856 ## - ELECTRONIC LOCATION AND ACCESS
Public note doi:10.1001/jamanetworkopen.2025.0955 (Open access)
Uniform Resource Identifier <a href="http://doi.org/10.1001/jamanetworkopen.2025.0955">http://doi.org/10.1001/jamanetworkopen.2025.0955</a>
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme Dewey Decimal Classification
Koha item type Journal article
Classification part news132
Holdings
Withdrawn status Lost status Source of classification or shelving scheme Damaged status Not for loan Home library Current library Date acquired Total Checkouts Full call number Barcode Date last seen Price effective from Koha item type
    Dewey Decimal Classification     Vine library Vine library 24/03/2025   Online ON25030029 24/03/2025 24/03/2025 Access online