Role of genotype in the cycle of violence in maltreated children (Record no. 2172)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02409nab a2200325Ia 4500 |
| 001 - CONTROL NUMBER | |
| control field | 112759 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250625151155.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 110331s2002 eng |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER | |
| International Standard Serial Number | 0036-8075 |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | WSS |
| Modifying agency | AFV |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Caspi, Avshalom |
| 9 (RLIN) | 897 |
| 245 ## - TITLE STATEMENT | |
| Title | Role of genotype in the cycle of violence in maltreated children |
| Statement of responsibility, etc | Caspi, Avshalom; McClay, Joseph; Moffitt, Terrie E.; Mill, Jonathan; Martin, Judy; Craig, Ian W.; Taylor, Alan; Poulton, Richie |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) | |
| Place of publication, distribution, etc | Washington, DC |
| Name of publisher, distributor, etc | American Association for the Advancement of Science |
| Date of publication, distribution, etc | 2002 |
| 365 ## - TRADE PRICE | |
| Price type code | 00 |
| Price amount | 0 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc | This paper presents the results of a study to determine why some children who are maltreated grow up to develop antisocial behaviour, whereas others do not. The study used data from a large sample of male children in Dunedin (New Zealand) from birth to adulthood. The study found that a functional polymorphism in the gene encoding the neurotransmitter-metabolizing enzyme monoamine oxidase A (MAOA) moderated the effect of maltreatment. As adults 85% of the severely maltreated children with a genotype conferring low levels of MAOA expression developed antisocial outcomes such as conviction for violent crimes. In contrast, maltreated children with a genotype conferring high levels of MAOA expression were less likely to develop antisocial problems. These findings may partly explain why not all victims of maltreatment grow up to victimize others, and provide epidemiological evidence that genotypes can moderate children's sensitivity to a poor environment. The MAOA low-activity genotype did not predict violence in the sample studied; its increased risk for violence was 'activated' by child maltreatment. This suggests the best strategy for violence prevention is preventing child abuse. It is recommended that researchers should measure stressful life events in genetic studies. |
| 500 ## - GENERAL NOTE | |
| General note | Science 297(5582) August 2002 : 851-854 |
| 650 27 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Source of heading or term | FVC |
| Topical term or geographic name as entry element | NEGLECT |
| 9 (RLIN) | 401 |
| 650 27 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 458 |
| Topical term or geographic name as entry element | PREVENTION |
| Source of heading or term | FVC |
| 650 27 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 103 |
| Topical term or geographic name as entry element | CHILD ABUSE |
| Source of heading or term | FVC |
| 651 24 - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME | |
| Geographic name | NEW ZEALAND |
| 9 (RLIN) | 2588 |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | McClay, Joseph |
| 9 (RLIN) | 1663 |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Moffitt, Terrie E. |
| 9 (RLIN) | 1743 |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mill, Jonathan |
| 9 (RLIN) | 1716 |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Martin, Judy |
| 9 (RLIN) | 1644 |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Craig, Ian W. |
| 9 (RLIN) | 989 |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Taylor, Alan |
| 9 (RLIN) | 2191 |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Poulton, Richie |
| 9 (RLIN) | 1937 |
| 773 0# - HOST ITEM ENTRY | |
| Title | Science 297(5582) August 2002 : 851-854 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Journal article |
| Withdrawn status | Lost status | Damaged status | Not for loan | Home library | Current library | Date acquired | Total Checkouts | Full call number | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Vine library | Vine library | 06/07/2011 | TRVF 000068 | A00668125B | 27/05/2013 | 06/07/2011 | Journal article |