Role of genotype in the cycle of violence in maltreated children (Record no. 2172)

MARC details
000 -LEADER
fixed length control field 02409nab a2200325Ia 4500
001 - CONTROL NUMBER
control field 112759
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20250625151155.0
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 110331s2002 eng
022 ## - INTERNATIONAL STANDARD SERIAL NUMBER
International Standard Serial Number 0036-8075
040 ## - CATALOGING SOURCE
Original cataloging agency WSS
Modifying agency AFV
100 ## - MAIN ENTRY--PERSONAL NAME
Personal name Caspi, Avshalom
9 (RLIN) 897
245 ## - TITLE STATEMENT
Title Role of genotype in the cycle of violence in maltreated children
Statement of responsibility, etc Caspi, Avshalom; McClay, Joseph; Moffitt, Terrie E.; Mill, Jonathan; Martin, Judy; Craig, Ian W.; Taylor, Alan; Poulton, Richie
260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT)
Place of publication, distribution, etc Washington, DC
Name of publisher, distributor, etc American Association for the Advancement of Science
Date of publication, distribution, etc 2002
365 ## - TRADE PRICE
Price type code 00
Price amount 0
520 ## - SUMMARY, ETC.
Summary, etc This paper presents the results of a study to determine why some children who are maltreated grow up to develop antisocial behaviour, whereas others do not. The study used data from a large sample of male children in Dunedin (New Zealand) from birth to adulthood. The study found that a functional polymorphism in the gene encoding the neurotransmitter-metabolizing enzyme monoamine oxidase A (MAOA) moderated the effect of maltreatment. As adults 85% of the severely maltreated children with a genotype conferring low levels of MAOA expression developed antisocial outcomes such as conviction for violent crimes. In contrast, maltreated children with a genotype conferring high levels of MAOA expression were less likely to develop antisocial problems. These findings may partly explain why not all victims of maltreatment grow up to victimize others, and provide epidemiological evidence that genotypes can moderate children's sensitivity to a poor environment. The MAOA low-activity genotype did not predict violence in the sample studied; its increased risk for violence was 'activated' by child maltreatment. This suggests the best strategy for violence prevention is preventing child abuse. It is recommended that researchers should measure stressful life events in genetic studies.
500 ## - GENERAL NOTE
General note Science 297(5582) August 2002 : 851-854
650 27 - SUBJECT ADDED ENTRY--TOPICAL TERM
Source of heading or term FVC
Topical term or geographic name as entry element NEGLECT
9 (RLIN) 401
650 27 - SUBJECT ADDED ENTRY--TOPICAL TERM
9 (RLIN) 458
Topical term or geographic name as entry element PREVENTION
Source of heading or term FVC
650 27 - SUBJECT ADDED ENTRY--TOPICAL TERM
9 (RLIN) 103
Topical term or geographic name as entry element CHILD ABUSE
Source of heading or term FVC
651 24 - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME
Geographic name NEW ZEALAND
9 (RLIN) 2588
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name McClay, Joseph
9 (RLIN) 1663
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Moffitt, Terrie E.
9 (RLIN) 1743
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Mill, Jonathan
9 (RLIN) 1716
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Martin, Judy
9 (RLIN) 1644
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Craig, Ian W.
9 (RLIN) 989
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Taylor, Alan
9 (RLIN) 2191
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Poulton, Richie
9 (RLIN) 1937
773 0# - HOST ITEM ENTRY
Title Science 297(5582) August 2002 : 851-854
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme Dewey Decimal Classification
Koha item type Journal article
Holdings
Withdrawn status Lost status Damaged status Not for loan Home library Current library Date acquired Total Checkouts Full call number Barcode Date last seen Price effective from Koha item type
        Vine library Vine library 06/07/2011   TRVF 000068 A00668125B 27/05/2013 06/07/2011 Journal article